DDP-38003 dihydrochloride

CAS No. 1831167-98-6

DDP-38003 dihydrochloride( DDP 38003 dihydrochloride | DDP38003 dihydrochloride )

Catalog No. M12821 CAS No. 1831167-98-6

DDP-38003 is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with IC50 of 84 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DDP-38003 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    DDP-38003 is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with IC50 of 84 nM.
  • Description
    DDP-38003 is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with IC50 of 84 nM; weakly inhibits MAO-A and has no activity for KDM1B and MAO-B (IC50>30 uM); orally bioactive and exhibits in vivo efficacy in mouse leukemia model.Blood Cancer Preclinical.
  • In Vitro
    DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue.
  • In Vivo
    DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent.
  • Synonyms
    DDP 38003 dihydrochloride | DDP38003 dihydrochloride
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    Histone Demethylase
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    1831167-98-6
  • Formula Weight
    423.37922
  • Molecular Formula
    C21H28Cl2N4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 29 mg/mL
  • SMILES
    CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C4CC4N.Cl.Cl
  • Chemical Name
    Benzamide, N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methyl-1-piperazinyl)-, hydrochloride (1:2)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Vianello P, et al. J Med Chem. 2016 Feb 25;59(4):1501-17.
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