DDP-38003 dihydrochloride ( DDP 38003 dihydrochloride;DDP38003 dihydrochloride )

Catalog No. M12821 CAS No. 1831167-98-6

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Product Name

DDP-38003 dihydrochloride
Note

Research use only, not for human use.
Brief Description

DDP-38003 is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with IC50 of 84 nM.
Description

DDP-38003 is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with IC50 of 84 nM; weakly inhibits MAO-A and has no activity for KDM1B and MAO-B (IC50>30 uM); orally bioactive and exhibits in vivo efficacy in mouse leukemia model.Blood Cancer Preclinical
Synonyms

DDP 38003 dihydrochloride;DDP38003 dihydrochloride
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

Cancer
Indication

Blood cancer

CAS Number

1831167-98-6
Formula Weight

423.38
Molecular Formula

C21H28Cl2N4O
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 29 mg/mL
SMILES

CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C4CC4N.Cl.Cl
Chemical Name

Benzamide, N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methyl-1-piperazinyl)-, hydrochloride (1:2)

1. Vianello P, et al. J Med Chem. 2016 Feb 25;59(4):1501-17.

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